The healthcare landscape is undergoing a transformative shift towards patient-centric approaches, prompting a reevaluation of traditional clinical trial methodologies. This paper aims to explore global trends in clinical trials aligned with the patient-centric paradigm, highlighting the utilization of Real-World Evidence (RWE), Big Data, AI, and cutting-edge technologies in clinical research. By examining cases that showcase the integration of these elements, we intend to provide insights into the evolving landscape of clinical studies. This discussion will underscore the importance of embracing novel methodologies and technologies to enhance the efficiency, inclusivity, and effectiveness of clinical research, ultimately contributing to the advancement of patient-centered healthcare practices.