• Chang Hun, Lee
  • Professor
  • Columbia University Medical Center

Curriculum Vitae

Education

Ph.D. Columbia University, New York, USA (2010)

Professional Experience

Associate Professor, Columbia University (2017 - present)
Assistant Professor, Columbia University (2014- 2017)
Associate Research Scientist, Columbia University (2010 - 2013)

Research Interests

3D printing embedded with controlled delivery system
In situ regeneration of meniscus and tendon

Honors & Awards

Invited Speaker, 6th Annual Musculoskeletal Repair and Regeneration Symposium (2017)
Best paper award (1st place), Meniscus section at Orthopedic Research Society (2017)
New Investigator Recognition Award, Orthopedic Research Society (2013)

Publications

1. Tarafder S, Koch A, Jun Y, Chu C, Awadallah MR, Lee CH+, Micro-Precise Spatiotemporal Delivery System Embedded in 3D Printing for Complex Tissue Regeneration, Biofabrication. 2016, 8(2):025003.
2. Lee CH+, Lee FY, Tarafder S, Kao K, Jun Y, Yang G, Mao JJ, Harnessing Endogenous Stem/Progenitor Cells for Tendon Regeneration, J Clin Invest. 2015, 1;125(7):2690-701
3. Lee CH, Rodeo SA, Fortier LA, Lu C, Erisken C, Mao JJ, Protein-Releasing Polymeric Scaffolds Induce Fibrochondrocytic Differentiation of Endogenous Cells for Knee Meniscus Regeneration in Sheep, Science Trans Med. 2014, 6(266):266ra171

Abstract

Advanced 3D printing for regenerative engineering

Three-dimensional (3D) printing is an emerging tool to fabricate scaffolds for tissue engineering and regenerative medicine, benefited by customized design, tunable internal microstructure, and a wide range applicable material. As a recent technical advancement, 3D printed scaffolds have been incorporated with a controlled delivery of growth factors and/or other bioactive cues to facilitate tissue regeneration, not only providing a temporal structural substrate for cell and tissue ingrowth. This presentation will cover a number of the recent advancements in incorporation of a controlled delivery system in 3D printed scaffolds from hydrogel adsorption and surface coating to chemical integration and embedding microspheres. We will also address the up-to-date research progress for regeneration of complex tissues with various stem/progenitor cells and the 3D printed scaffolds incorporated with controlled delivery systems. In addition, we will discuss the advantages and disadvantages of each delivery method integrated in 3D printed scaffolds, outstanding challenges and future directions.